Recent Advances in Multi-Modality Vascular Imaging
A Symposium for IEEE EMBS 2006, New York, NY. Jasjit S. Suri, PhD., Fellow AIMBE, Fellow ABI, SrMIEEE, MAAPM
Biomedical Research Institute, Idaho & Biomedical Technologies, Inc.
Email: suri0256@msn.com
Thursday, August 31, 2006; 2.00PM-3.30 PM Symposium Chair & Speaker
Andreas Wahle, PhD., (Speaker)
University of Iowa, IA, USA Aaron Fenster, PhD. (Speaker)
Imaging Research Laboratories, Robarts Research Institute
London, Ontario, CANADA Theme of Symposium Recent advances in Angiography and Plaque Imaging have led to better understanding of blood vessel diseases such as stroke and atherosclerosis. Both angiography and plaque imaging are linked very closely to each other. Proper medical knowledge of plaque morphology and its composition are essential for efficient and successful clinical assessments of atherosclerotic disease. For example, MRI is used to provide: non-invasive characterization of carotid plaque development, reliable biomarkers for clinical trials to evaluate the effectiveness of new anti-atherosclerotic therapies, a better understanding of the pathogenesis of cardiovascular disease, and an assessment of the risk of clinical events. Similarly, non-invasive 3-D ultrasound is also being used for understanding of the progression and regression of atherosclerosis and monitoring of changes in atherosclerosis plaques. Description of the Mini-Symposia The Symposium is organized into 3 parts: Part-I will focus on segmentation of blood vessels for MR, CT, IVUS techniques and plaque composition. This introduces scale-space strategies for white and black blood MRI. Part three presents the implications of this knowledge. The third part begins with an overview of the technical and technological aspects of MR imaging of carotid atherosclerosis, highlighting the advantages of MRI over other modalities for both clinical and research use. What constitutes a practical imaging protocol will then be discussed and clarified. And finally, we will consider how plaque imaging techniques can be best applied for clinical use. Part-II will include identification of vulnerable carotid plaques and plaque changes that are likely to rupture leading to thrombogenic events. These developments have the potential to the next leap in management of patients at risk for stroke. 3D ultrasound (3D US) studies allow the investigation of plaque volume, surface morphology and changes due to disease progression or regression. Part-III of the Symposium will present fusion techniques for in vivo angiography and intravascular ultrasound data. Computational-fluid-dynamics simulations of coronary hemodynamics along with morphological analyses of plaque thickness and local curvature allow further insight into the mechanisms of atherosclerosis and the verification of common hypotheses. Part-I ADVANCES IN 3-D VASCULAR MRI
The talk will focus on segmentation of blood vessels for MR, CT, IVUS techniques and plaque composition. This introduces scale-space strategies for white and black blood MRI. In this part, we will also present the usage of dynamic thresholding techniques in scale-space frame work. This is very useful for removing noise which some times occludes think blood vessels. Several different algorithms will be compared and evaluated. Another part of this talk will focus on carotid atherosclerosis, highlighting the advantages of MRI over other modalities for both clinical and research use. What constitutes a practical imaging protocol will then be discussed and clarified. And finally, we will consider how plaque imaging techniques can be best applied for clinical use. Part-II ADVANCES IN 3-D VASCULAR ULTRASOUND IMAGING
The last two decades have witnessed unprecedented developments of new imaging systems making use of 3D visualization. These new technologies have revolutionized diagnostic radiology, as they provide information about the interior of the human body never before available. These developments have clearly demonstrated that 2D viewing of 3D anatomy, using conventional techniques, limits our ability to quantify and visualize a number of diseases and is partly responsible for the reported variability in diagnosis and in guiding minimally invasive surgical procedures. Developments that will be described will focus on advances in 3D vascular ultrasound. Examples will be discussed in the use of these techniques for quantitative morphological and functional vascular imaging. These advances have involved multi-disciplinary efforts integrating expertise of radiologists with computer scientists, engineers and physicists. Areas that will be covered in the presentation will include identification of vulnerable carotid plaques and plaque changes that are likely to rupture leading to thrombogenic events. These developments have the potential to the next leap in management of patients at risk for stroke. 3D ultrasound (3D US) studies allow the investigation of plaque volume, surface morphology and changes due to disease progression or regression. Part-III 3-D QUANTITATIVE ANALYSIS OF CORONARY PLAQUE DISTRIBUTION BY MULTIMODALITY FUSION
Many questions are still open concerning the interactions among vessel geometry, resulting wall shear stresses, and subsequent plaque development. It has been observed that plaque tends to accumulate more frequently in locations of relatively low wall shear stress in the onset of coronary atherosclerosis. To obtain 3-D and 4-D models of the coronary arteries suitable for quantitative analysis, we have developed and validated a fusion technique for in-vivo angiography and intravascular ultrasound data. Computational-fluid-dynamics simulations of coronary hemodynamics along with morphological analyses of plaque thickness and local curvature allow further insight into the mechanisms of atherosclerosis and the verification of common hypotheses. RECOMMENDED BOOKS AND JOURNALS OF THE TEAM -
Jasjit S. Suri and Swamy Laxminarayan, “Angiography Imaging”, CRC Press, 2003. -
Jasjit S. Suri, Chun Yuan, David Wilson and Swamy Laximarayan, “Plaque Imaging: Pixels to Molecular Levels”, IOS Press, The Netherlands, 2005. -
Jasjit S. Suri and Aly Farag, Deformable Models: An application to Medical Imaging (Volume-I) Springer, May 2006. -
Jasjit S. Suri and Aly Farag, Deformable Models: An Application to Medical Imagery (Volume-II), Springer, May 2006. -
Jasjit S. Suri et al., Hand Book of Biomedical Image Analysis (Volume-I, Volume-II, Volume-III), Editors: Suri, J. S., Wilson, D. L., and Laxminarayan, S., Springer, 2005 (www.amazon.com). -
Jasjit S. Suri (with Liu, K., Laxminarayan, S., Reden, L.) Ellipsoidal Scale-Space
Filtering of Magnetic Resonance Angiographic Data Sets, IEEE Transactions of Information Technology in Biomedicine, Vol. 6, No. 4, Page(s):324 – 337, Dec. 2002. -
Jasjit S. Suri, Liu, K., Singh, S., Laxminarayan, S., Reden, L., “A Current Survey on Vascular Segmentation Using Magnetic Resonance Angiography Data Sets”, Part-I, IEEE Trans. of Information Tech. in Biomedicine, Volume 6, Issue 4, Dec. 2002 Page(s): 338 – 350, Dec. 2002. -
Fenster A, Downey DB. Three-dimensional ultrasound imaging and its use in quantifying organ and pathology volumes. Anal Bioanal Chem. 377(6): 982-989, 2003. -
Landry A, Spence JD, Fenster A. Measurement of carotid plaque volume by 3-dimensional ultrasound. Stroke. 35(4): 864-869, Mar 2004. -
Fenster A, Landry A, Downey DB, Hegele RA, Spence JD. 3D Ultrasound Imaging of the Carotid Arteries. Current Drug Targets. 4(2): 161-175, Jun 2004. -
Landry A, Spence JD, Fenster A. Quantification of carotid plaque volume measurements using 3D ultrasound imaging. Ultrasound Med Biol. 31(6): 751-762, May 2005. -
Ainsworth CD, Blake CC, Tamayo A, Beletsky V, Fenster A, Spence JD. 3-Dimensional ultrasound measurement of change in carotid plaque volume: A tool for rapid evaluation of new therapies. Stroke. 36(9): 1904-1909, Sep 2005. -
Wahle A (with Chandran KB, Vigmostad SC, Olszewski ME, Rossen JD, Sonka M): Coronary Arteries: Imaging, Reconstruction, and Fluid Dynamic Analysis. Critical Reviews in Biomedical Engineering, Begellhouse, New York, expected 2006 -
Wahle A, Olszewski ME, Sonka M: Interactive Virtual Endoscopy in Coronary Arteries based on Multi-Modality Fusion. IEEE Transactions on Medical Imaging, IEEE Press, Volume 23(11), pp. 1391-1403, November 2004 -
Wahle A, Lopez JJ, Pennington EC, Meeks SL, Braddy KC, Fox JM, Brennan TMH, Buatti JM, Rossen JD, Sonka M: Effects of Vessel Geometry and Catheter Position on Dose Delivery in Intracoronary Brachytherapy. IEEE Transactions on Biomedical Engineering, IEEE Press, Volume 50(11), pp. 1286-1295, November 2003 -
Wahle A (with Medina R, Olszewski ME, Sonka M): Three Methods for Accurate Quantification of Plaque Volume in Coronary Arteries. International Journal of Cardiovascular Imaging, Kluwer, Volume 19(4), pp. 301-311, August 2003 -
Wahle A (with Stone PH, Coskun AU, Kinlay S, Clark ME, Sonka M, Ilegbusi OJ, Yeghiazarians Y, Popma JJ, Orav J, Kuntz RE, Feldman CL): Effect of Endothelial Shear Stress on the Progression of Coronary Artery Disease, Vascular Remodeling, and In-stent Restenosis in Man; In-Vivo 6-Month Followup Study, Circulation, Volume 108(4), pp. 438-444, July 2003. -
Wahle A, Prause GPM, DeJong SC, Sonka M: Geometrically Correct 3-D Reconstruction of Intravascular Ultrasound Images by Fusion with Biplane Angiography - Methods and Validation, IEEE Transactions on Medical Imaging, IEEE Press, Volume 18(8), pp. 686-699, August 1999. -
Wahle A, Wellnhofer E, Mugaragu I, Sauer HU, Oswald H, Fleck E: Assessment of Diffuse Coronary Artery Disease by Quantitative Analysis of Coronary Morphology based upon 3-D Reconstruction from Biplane Angiograms. Transactions on Medical Imaging, IEEE Press, Volume 14(2), pp. 230-241, June 1995
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